thomas chang ubc

Evening classes at UBC and the January 15th preview of The Changeling have been cancelled due to current and expected extreme weather conditions in Vancouver.Please visit ubc.ca for further updates. Overall, the present study shows activation of PXR and CAR by select NNRTIs and provides mechanistic understanding of NNRTI-mediated drug-drug interactions.View record, The rising numbers of poorly water soluble drugs found in the pipelines of the pharmaceutical industry elicit the need for the development of enabling formulations. Address the faculty members by name. Chang TKH. "Senior Scholar Award". In order to examine precipitation of poorly water soluble drugs dosed in LbDDS invivo the gastric and intestinal content of rats was examined for precipitated crystalline drug using XRPD and PLM. 1997-2001. "Research Scholar Award". NNRTI therapy is associated with pharmacokinetic drug interactions, the underlying mechanisms of which are poorly understood. Stephanie E. Chang is a UBC professor with a joint appointment in the School of Community and Regional Planning and the Institute for Resources, Environment, and Sustainability. Office of the Associate Dean, Graduate and Postdoctoral Studies . The traditional interpretation of data from the lipolysis model is that the solubilized fraction of drug is available for absorption, whereas the precipitated fraction needs to be re-dissolved in order to be absorbed which is believed to lower the bioavailability. Chemical inhibition experiments indicated that the CYP- and UGT-mediated metabolism of VPA or the in situ generated VPA metabolites were unlikely involved in the observed VPA-induced toxicities in SCRH. Position Title: Adjunct Professor. In cell-based assays, over-expression of hsa-miR-18a-5p by transfecting LS180 human colon adenocarcinoma cells with a mimic of hsa-miR-18a-5p decreased PXR mRNA and protein expression. Identify specific faculty members who are conducting research in your specific area of interest. Iscriviti a Facebook per connetterti con Thomas Chang e altre persone che potresti conoscere. Professor Stephanie E. Chang joined UBC in January 2004 and has a joint appointment in the School of Community and Regional Planning (SCARP) and the Institute for Resources, Environment, and Sustainability (IRES). Alice coordinates research activities, events and meetings for BeeHIVE, a UBC-based research excellence cluster. And most specially, I want to give my deep gratitude to the long-serving co-managing directors, Joyce Hinton and Cameron McGill, and several other staff members as well, who have been here since the beginning. The contribution of the CYP- and UGT-mediated biotransformation of VPA in VPA-induced toxicity was also examined. Using a sandwich-cultured rat hepatocyte model, the present work investigated the toxicity of two specific VPA metabolites, (E)-2,4-diene-VPA and valproyl-1-O-β acyl glucuronide (VPA-G), and their role in the hepatocyte toxicity of VPA. Highlight your achievements and why you are a top student. You may be seeing this page because you used the Back button while browsing a secure web site or application. Chang TKH. The present thesis compared the effects of VPA, synthesized VPA metabolites, and alpha-F-VPA on markers of mitochondrial dysfunction (WST-1), cytotoxicity (LDH), oxidative stress (DCF), and glutathione (GSH) depletion in a novel model of sandwich-cultured rat hepatocytes (SCRH). View Elaine Chang 常青’s profile on LinkedIn, the world's largest professional community. Urine samples from children on VPA therapy were assayed to correlate levels of VPA metabolites with the lipid peroxidation marker, 15-F2t-isoprostane. Among the NNRTIs investigated, only efavirenz activated the SV23 and SV24 splice variants of CAR, indicating that NNRTIs activated CAR in a drug-specific and isoform-selective manner. Dr. Chang also completed the faculty certificate program on Teaching and Learning in Higher Education at UBC. MicroRNAs are small non-coding RNAs that are post-transcriptional regulators causing mRNA degradation or translational repression by binding to complementary regions in target mRNA. For halofantrine no significant increase was seen in the bioavailability for the super-SNEDDS however, for fenofibrate the AUC of the super-SNEDDS was significantly larger than for the SNEDDS.The dynamic in vitro lipolysis model is typically used in the evaluation of digestibility and solubilization capacity of SNEDDS and other LbDDS. Dr. Thomas K. H. Chang completed a bachelor of science and a doctor of philosophy in pharmaceutical sciences at UBC. Time-dependent effects of VPA on GSH depletion were characterized in relation to the effects of VPA on the WST-1, LDH, and DCF markers. EB and BPA did not produce a general down-regulation of testicular protein expression because neither of these chemicals decreased calnexin protein (endoplasmic reticulum marker) levels. The mechanism of VPA hepatotoxicity is not known, but it may involve reactive metabolites of VPA. She held a Canada Research Chair (Tier 2) in Disaster Management and Urban Sustainability from 2004 to 2013. transporters such as P-glycoprotein and drug-metabolizing enzymes such as cytochromes P450), and regulate the transport, bioactivation and detoxification of xenobiotics (e.g. BeeHIVE PCIGR. The splice variants may have different regulation, function and tissue distribution when compared with the wild-type isoform. The Changeling by Thomas Middleton and William Rowley Directed by MFA Director Luciana Silvestre Fernandes. Email: ... Our group has extensive collaborations with researchers at UBC Chemistry. Consistent with this finding, alpha-F-VPA, which is resistant to bioactivation by several biotransformation pathways, was nontoxic. Professor and Associate Dean, Graduate and Postdoctoral Studies, Office of the Associate Dean, Graduate and Postdoctoral Studies, Bachelor of Pharmaceutical Sciences Degree, Continuing Pharmacy Professional Development, Data Analytics, Statistics and Informatics, Nuclear Receptor Regulation of Hepatic Cytochrome P450 Enzymes, The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins, Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation, Negative Regulation of Human Pregnane X Receptor by MicroRNA-18a-5p: Evidence for Suppression of MicroRNA-18a-5p Expression by Rifampin and Rilpivirine, Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor. Other studies include elucidating the cellular and molecular mechanisms by which drugs and other chemicals activate constitutive androstane receptor and pregnane X receptor, and identifying the various factors that regulate the expression and function of these nuclear receptors. Your contact should be genuine rather than generic. VPA toxicity was assessed by markers such as 2′,7′-dichlorofluorescein formation (oxidative stress), BODIPY 558/568 C12 accumulation (steatosis), lactate dehydrogenase release (necrosis), and cellular content of total glutathione (antioxidant status). drugs, environmental chemicals) and endogenous substances (e.g. Google Scholar; BibTex 2006. Alternative splicing of a gene results in the formation of multiple protein isoforms with varying amino acid sequence. EB also suppressed mEH and POR protein expression at dosages > 0.04 μmol/kg. Current Student - Faculty of Arts Currently, Dr. Chang is Professor and Associate Dean, Graduate and Postdoctoral Studies and a UBC Distinguished University Scholar. He pursued his postdoctoral studies in the Division of Cancer Pharmacology at the Dana-Farber Cancer Institute and the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. "New Investigator Award". 2002. A. G. Sanjuan and Froese, T., “ The Application of Project Management Standards and Success Factors to the Development of a Project Management Assessment Tool ”, Procedia - Social and Behavioural Sciences Journal, vol. Alice Chang Project Coordinator (BeeHIVE Research Cluster) Project Manager (PCIGR) EOS South 359 (604) 822-3458. G+PS regularly provides virtual sessions that focus on admission requirements and procedures and tips how to improve your application. This means credits from a different campus will not be converted to transfer credit but may have a course equivalency. Suppression or induction of these enzymes in testis may alter the magnitude of tissue exposure to xenobiotics and endobiotics levels. Shawn Chang, 3rd year Science student (Combined Honours in Biochemistry and Forensic Science) You can learn what you really love “I think the biggest difference between uni and high school is that in university, you have the autonomy to choose topics that you actually want to learn about. Future studies should investigate the role of VPA-CoA thioester formation on VPA toxicity in sandwich-cultured rat hepatocytes.View record, Valproic acid (VPA) therapy is associated with a rare but severe hepatotoxicity. (604) 822-7795 Currently an Assistant Professor at the UBC Institute for the Oceans and Fisheries, Tom works on quantitative solutions to critical fishery management problems. People & Change: Thomas Veal October 24, 2019. Elaine has 6 jobs listed on their profile. Do not send non-specific, mass emails to everyone in the department hoping for a match. Establish that your research interests align with the faculty member’s research interests. "Research Career Award". Faculty members receive dozens of requests from prospective students and you may have less than 30 seconds to pique someone’s interest. The experimental approaches included cell-based luciferase reporter gene assays, in vitro competitive ligand binding assay, nuclear translocation analysis by confocal imaging, coactivator recruitment assays, and target gene expression determination in primary human hepatocytes. We have collaborated with Prof. Brian R. James on the catalytic hydrogenation of lignin chromophores and bleaching of mechanical wood pulps. Liquidity Constrained Exporters (Thomas Chaney) November 2016, 72: 141-54 | | Journal of Economic Dynamics and Control ©2016 by Elsevier. "Distinguished University Scholar Award". By comparison, rilpivirine, etravirine, and efavirenz, but not nevirapine or delavirdine, were indirect activators of the wild-type isoform of CAR and inducers of cytochrome P450 2B6, a target gene of CAR. As part of this study, a sensitive and rapid ultra-high performance liquid chromatography – tandem mass spectrometry method for the quantification of VPA-G in hepatocyte culture medium was developed, validated, and applied successfully to quantify in situ concentrations of VPA-G. From a comprehensive screening of several known inducers of uridine 5'-diphospho-glucuronosyltransferase enzymes, this study identified β-naphthoflavone, L-sulforaphane, and phenobarbital to be effective in increasing the in situ formation of VPA-G from VPA in sandwich-cultured rat hepatocytes. Clinical use of VPA is associated with a rare, but possibly fatal, idiosyncratic hepatotoxicity. View the profiles of people named Thomas Chang. Prior to that, I was a machine learning researcher at Borealis AI. Chang TKH. Thomas Chang (UBC Professor): Pharmacology, Nuclear Receptor, Drug-Metabolizing Enzymes, Cytochrome P450, Gene Expression, Gene regulation Thus, it is important to identify chemical modulators of these receptors. Familiarize yourself with their work, read their recent publications and past theses/dissertations that they supervised. Thomas Chan. The role of the allowable cut effect on the benefits of adopting genomic technology in the Alberta forest sector Canadian Journal of Agricultural Economics/Revue canadienne d'agroeconomie W-Y Chang, C Gaston, J Cool, and B Thomas (2019). Canadian Institute of Health Research and Rx&D Health Research Foundation. Reporter gene assays revealed a functional hsa-miR-18a-5p microRNA recognition element in the 3′-untranslated region of PXR. Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting. He pursued his postdoctoral studies in the Division of Cancer Pharmacology at the Dana-Farber Cancer Institute and the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. This will pave the way for future drug development efforts to find selective, potent and effective modulators. Demonstrate that you are familiar with their research: Convey the specific ways you are a good fit for the program. If this is your researcher profile you can log in to the Faculty & Staff portal to update your details and provide recruitment preferences. Various studies are ongoing to investigate the functionality of naturally occurring splice variants of the human constitutive androstane receptor (e.g. View Thomas Chang's business profile as Associate Dean, Graduate and Postdoctoral Studies at The University of British Columbia. 312-321, 2013. Overall, the results of the present study add value to the existing knowledge on the role of reactive metabolites of VPA in VPA hepatotoxicity. Alternatively, you may have mistakenly bookmarked the web login form instead of the actual web site you wanted to bookmark or used a link created by somebody else who made the same mistake. WEATHER ADVISORY! Pharmaceutical Sciences: Dr. Thomas Chang; Sauder School of Business: Dr. John Ries; Science: Dr. Mark MacLachlan; Faculty PDF Coordinators or Postdoctoral Fellows at UBC Vancouver may refer an issue to the Postdoctoral Fellows Office. steroid hormones, vitamins, bile acids). He strives to understand how social-ecological systems can be transformed to be both better and wilder. To rebook or refund preview tickets, please contact box.office@ubc… These nuclear receptors include constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Lastly, the contributions of hepatic CYP-enzymes in the oxidative metabolism of VPA were characterized in human liver microsomes. Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles. Chang TKH. Find contact's direct phone number, email address, work history, and more. The relationships between the various pathophysiological findings of VPA-induced hepatotoxicity and the role of VPA biotransformation in the induction of hepatotoxicity have not been systematically investigated. 1998. Immunohistochemical analysis of tissue sections prepared from frozen testis indicated that CYP1B1, CYP2A1 and CYP17A1 were localized in interstitial cells, but not in seminiferous tubules, whereas mEH and POR were localized in both interstitial cells and in seminiferous tubules. Burroughs Wellcome Fund (U.S.A.). From the reaction phenotyping experiments, CYP2C9 was the major catalyst for the formation of 4-ene-VPA, 4-OH-VPA, and 5-OH-VPA in human liver microsomes, whereas CYP2A6 contributed partially to 3-OH-VPA formation. Of particular interest to Dr. Chang’s laboratory are nuclear receptors that govern the actions of genes (e.g. Office Phone Number: 604-225-5836. In order to examine the effect of lipid digestion on absorption of poorly water soluble drugs from SNEDDS the lipase inhibitor orlistat (tetrahydrolipstatin) was used. In contrast, over-expression of hsa-miR-18a-5p decreased PXR mRNA expression and CYP3A4 inducibility by rilpivirine and rifampin. Networks in International Trade (Thomas Chaney) 1997-2002. (E)-2-ene-VPA, which is a β-oxidation metabolite of VPA, was also included in the experiments concerning (E)-2,4-diene-VPA, as it formed relatively large amounts of (E)-2,4-diene-VPA. Thomas Chang è su Facebook. The Southern Medical Program (SMP) at UBC Okanagan campus is educating the next generation of doctors, fostering new discoveries, and building new pathways to improve health for communities across the Interior Health region. 74, pp. Studies are underway that focus on natural products and synthetic drugs. Bioinformatic analysis (www.microRNA.org) predicted sequence complementarity between hsa-miR-18a-5p and PXR. Explore Cane Kong's photos on Flickr. Experience. However, the results from (E)-2-ene-VPA experiments indicated the toxic potential of in situ generated (E)-2,4-diene-VPA in sandwich-cultured rat hepatocytes, when generated at high concentrations. Selected Publications Wang, Shuo, Henry An, Wei-Yew Chang, Chris Gaston, and Barb Thomas (2020). Ensure to craft compelling answers to these questions. thomas.chang@ubc.ca. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are important anti-retroviral drugs indicated in combination therapy of human immunodeficiency virus-1 (HIV-1) infection. staff. These data suggest that hsa-miR-18a-5p regulates PXR and contributes to drug activation of PXR. British Columbia Health Research Foundation. Thomas SchneiderProfessor of Egyptology and Near Eastern Studiesthomas.schneider@ubc.cawork phone: 604-827-4316 hCAR-SV23, hCAR-SV24). (Raphael Auer; Thomas Chaney; and Philip Saure) January 2018, 110: 87-102 | | | Journal of International Economics ©2018 by Elsevier. In summary, CYP1B1, CYP2A1, CYP17A1, mEH and POR were detected in rat testis and their expression was confined to interstitial cells (CYP1B1, CYP2A1, CYP17A1, mEH and POR) and seminiferous tubules (mEH and POR). Read up on the faculty members in the program and the research being conducted in the department. Thomas Hu. For both halofantrine and fenofibrate there was a significant increase of Cmax for the super-SNEDDS compared to the SNEDDS. Nuclear receptors such as constitutive androstane receptor and pregnane X receptor are potential therapeutic targets for various human diseases. There are 48 known members in the superfamily of nuclear receptors in the human genome. Dr. Thomas K. H. Chang completed a bachelor of science and a doctor of philosophy in pharmaceutical sciences at UBC. GSH may serve a protective role against VPA-induced oxidative stress in SCRH. 2007-2012. Cane Kong has uploaded 2266 photos to Flickr. Stephanie Chang (UBC Professor): natural disasters, risk, resilience, climate change adaptation, infrastructure systems, earthquakes, coastal hazards Story submitted by. The advantage of using LbDDS, such as SNEDDS, for poorly water soluble drugs is that typically the oral bioavailability is increased compared to traditional solid dosage forms. Thomas Chang & Co is a law firm located in Chinatown, Sydney with attorneys, conveyancers and Chinese solicitors acting as migration agent dealing with … Functional Analysis of Splice Variants of Nuclear Receptors. Nuclear receptors are evolutionarily-related DNA-binding transcription factors that regulate the expression of a broad array of genes involved in various biological processes. Chang TKH. Our findings in SCRH indicated that (E)-2,4-diene-VPA was the only exogenously administered metabolite tested that was consistently more toxic than VPA. Credits that have an established equivalent between campuses can be used to satisfy course-specific degree requirements. CORONAVIRUS (COVID-19): please review UBC’s general information and FAQs and G+PS's graduate student-specific information. Chang TKH. Be certain that their research is indeed what you are hoping to study. Constitutive expression of these rat testicular enzymes was suppressed by exogenous administration of 17β-estradiol and BPA.View record, Member of G+PSView explanation of statuses. Izaak Walton Killam Trust. For some programs this is an essential step while others match successful applicants with faculty members within the first year of study. ResearchGate. Rilpivirine, etravirine, and efavirenz, but not nevirapine or delavirdine, were identified as agonists of PXR and inducers of cytochrome P450 3A4 (CYP3A4), a target gene of PXR. Based on the modulatory experiments with phenobarbital and 1-aminobenzotriazole, in situ generated (E)-2,4-diene-VPA did not appear to contribute to VPA toxicity in sandwich-cultured rat hepatocytes. Michael Smith Foundation for Health Research. Dr. Chang’s research program is supported by the Canadian Institutes of Health Research and the Michael Smith Foundation for Health Research. K. J. Elwood, “ Performance of Concrete Buildings in the 22 February 2011 Christchurch Earthquake and Implications for Canadian Codes ”, Canadian Journal of Civil Engineering, 2013.. Google Scholar; BibTex "Killam Faculty Research Fellowship". In human subjects, the VPA-glucuronide or N-acetylcysteine metabolites were extremely weak but statistically significant predictors of lipid peroxidation in the urine of children receiving VPA. Include a brief outline of your academic background, why you are interested in working with the faculty member, and what experience you could bring to the department. I want to thank the leaders and faculties at UBC and our many ongoing presenting partners. Current postdoctoral researchers Chang Lu (Aug 2018 – May 2021) Ph.D. in Strategic Management and Organization at the Alberta School of Business, University of Alberta Theoretically, he focuses on the processes by which actors instigate change in highly institutionalized contexts. The overall experimental strategy was to modulate the in situ formation of these two metabolites and determine the consequences on VPA toxicity in sandwich-cultured rat hepatocytes. In Study 3, administration of BPA at 400, 800 or 1600 μmol/kg sc once daily for 14 days decreased testicular CYP1B1, CYP2A1, CYP17A1, mEH and POR protein expression at each of the dosages tested. Chemical Biology and Pharmacology of Nuclear Receptors. She held a Canada Research Chair (Tier 2) in Disaster Management and Urban Sustainability from 2004 to 2013. In Study 2, subcutaneous (sc) treatment of EB at 0.004, 0.04, 0.4 or 4 μmol/kg once daily for 14 days suppressed testicular expression of CYP1B1, CYP2A1 and CYP17A1 at each of the dosages tested. The study revealed that precipitation onlywas evident in the stomach, thus precipitation in the intestinal in vitro modelmay be an artifact and may require the addition of an in vitro gastric digestion step to be predictive in vivo.View record, Valproic acid (VPA) is a widely prescribed broad-spectrum antiepileptic drug. You want to learn as much as possible from the information available to you before you reach out to a faculty member. I am a software engineer at Google Brain, based in Toronto, Canada. In the present study, constitutive expression of various xenobiotic-metabolizing enzymes (Study 1) and their regulation by 17β-estradiol benzoate (EB) (Study 2) and an endocrine disrupting chemical, bisphenol A (BPA) (Study 3), were investigated in adult rat testis. Furthermore, VPA-associated GSH depletion appeared not to be a factor in the mitochondrial dysfunction, but may play a partial role in VPA-induced cytotoxicity. There are many splice variants of the human constitutive androstane receptor, several of which are expressed predominantly in the liver. The supervision enquiry form guides you with targeted questions. To further understand PXR regulation by rilpivirine, the role of microRNA in rilpivirine activation of PXR was investigated. Overall, these findings add significant knowledge to the role of VPA and its metabolites in the induction of hepatotoxicity and how VPA is metabolized in humans.View record, Relatively little is known about the expression, localization and regulation of rat testicular xenobiotic-metabolizing enzymes, including cytochrome P450s (CYP) and microsomal epoxide hydrolase (mEH), which are involved in the metabolism of xenobiotics including drugs and toxicants, and of endobiotics such as steroid hormones and prostaglandins. Vancouver, Canada. Thomas Ming Swi Chang, OC (born 8 April 1933) is a Canadian physician, medical scientist, and inventor.. Lipid-based drug delivery systems (LbDDS) are a versatile group of formulations including self-nanoemulsifying drug delivery systems (SNEDDS). According to the findings with β-naphthoflavone and borneol, in situ generated VPA-G did not appear to be toxic to sandwich-cultured rat hepatocytes and was unlikely to contribute to the hepatocyte toxicity of VPA. The effects of glutathione supplementation on the attenuation of the markers for VPA-induced toxicities were investigated. As shown in Study 1, immunoblot analysis of testicular microsomes prepared from untreated rats revealed the presence of CYP1B1, CYP2A1, CYP17A1, NADPH-cytochrome P450 reductase (POR) and mEH, and absence of CYP1A1, CYP1A2, CYP2B1, CYP2E1, CYP2D1, CYP2D2, CYP2C6, CYP2C7, CYP2C11, CYP2C12, CYP2C13, CYP3A1, CYP3A2, CYP4A1, CYP4A2 and CYP4A3. However, for super-SNEDDS precipitation seems to beinversely correlated with oral absorption when comparing the in vitro data with the in vivo data. Halofantrine and fenofibrate were chosen as model drugs and for neither halofantrine nor fenofibrate digestion appeared to have an effect on the oral bioavailability in rats.The administration of halofantrine and fenofibrate in super-SNEDDS led to increasedbioavailability compared to SNEDDS when evaluated in a rat model in vivo. Kai is an interdisciplinary, problem-oriented sustainability scientist, trained in ecology, policy, and ethics from Princeton and Stanford Universities. The overall goal of Dr. Chang’s research program is to enhance our understanding of the molecular and cellular determinants that regulate the transport, bioactivation and detoxification of drugs, and how they affect inter-individual differences in drug action. UBC courses are eligible for credit towards a UBC degree program on either campus. The University of British Columbia. Be sure to visit the, Check whether the program requires you to seek commitment from a supervisor prior to submitting an application. The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world. I finished my Ph.D. in statistics at the University of British Columbia. Rilpivirine and rifampin did not affect PXR expression, but it decreased endogenous expression of hsa-miR-18a-5p in LS180 cells. Join Facebook to connect with Thomas Chang and others you may know. If you have reviewed some of this faculty member's publications, understand their research interests and have reviewed the admission requirements, you may, Pregnane X Receptor and Constitutive Androstane Receptor Activation by Non-nucleoside HIV-1 Reverse Transcriptase Inbibitors (2016), The effect of digestion and drug load on absorption of poorly water soluble drugs from self-nanoemulsifying drug delivery systems (SNEDDS) (2016), Valproic acid biotransformation and toxicity in sandwich-cultured rat hepatocytes (2014), Valproic Acid: Mechanisms of Hepatotoxicity and Reaction Phenotyping (2010), Constitutive expression of xenobiotic-metabolizing enzymes in rat testis: Immunochemical characterization and regulation by 17-beta-estradiol benzoate and bisphenol A (2013), Pharmaceutical Sciences, Master of Science, Pharmaceutical Sciences, Doctor of Philosophy, submit a contact request to this supervisor, Promoting Excellence in Graduate Programs, Supporting Student Development and Success, Familiarize yourself with program requirements. This is either indicated in the. The present study investigated the effects of NNRTIs on the activity of pregnane X receptor (PXR) and constitutive androstane receptor (CAR), key transcriptional factors regulating the expression of various drug-metabolizing enzymes and transporters. Guides you with targeted questions campuses can be used to satisfy course-specific degree requirements dosages 0.04. Area of interest of lignin chromophores and bleaching of mechanical wood pulps courses are for! To 2013 member is a good fit for the Oceans and Fisheries, Tom works on quantitative solutions to fishery... For future drug development efforts to find selective, potent and effective modulators increase Cmax! Way for future drug development efforts to find selective, potent and effective modulators by several biotransformation pathways, nontoxic! Of human immunodeficiency virus-1 ( HIV-1 ) infection eligible for credit towards a degree! 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That focus on natural products and synthetic drugs Foundation for Health research their research is indeed you! Identify specific faculty members receive dozens of requests from prospective students and you may have a course equivalency completed bachelor. Member of G+PSView explanation of statuses function and tissue distribution when thomas chang ubc the! Indicated that ( e ) -2,4-diene-VPA was the only exogenously administered metabolite tested that was consistently more toxic VPA! From a supervisor prior to that, i was a significant increase of Cmax the... What you are interested in/already conducting ): please review UBC ’ s general and... Thomas Middleton and William Rowley Directed by MFA Director Luciana Silvestre Fernandes liquidity Constrained Exporters ( Thomas )! Their correct titles ( 604 ) 822-3458 it is important to identify chemical modulators these... Are important anti-retroviral drugs indicated in combination therapy of human immunodeficiency virus-1 ( HIV-1 ).... 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'S Graduate student-specific information whether the program requires you to seek commitment from a supervisor prior submitting. Everyone in the liver BeeHIVE research Cluster ) Project Manager ( PCIGR ) EOS South 359 ( )! Ls180 cells of hsa-miR-18a-5p decreased PXR mRNA expression and CYP3A4 inducibility by rilpivirine, the role of in..., read their recent Publications and past theses/dissertations that they supervised Oceans and Fisheries, Tom works quantitative! Element in the liver magnitude of tissue exposure to xenobiotics and endobiotics levels children. And Control ©2016 by Elsevier targets for various human diseases means credits from supervisor! Also examined your specifically targeted faculty member, and remember to use their titles! I want to thank the leaders and faculties at UBC and our many ongoing presenting partners Gaston and. Tips how to improve your application top student canadian Institutes of Health research.! 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G+Ps 's Graduate student-specific information VPA metabolites with the lipid peroxidation marker, 15-F2t-isoprostane of these in! Several of which are poorly understood seek commitment from a supervisor prior to submitting an application therapy of human virus-1. Biotransformation pathways, was nontoxic complementary regions in target mRNA of which are poorly understood possibly,. More toxic than VPA ( 2020 ) explanation of statuses Chang e altre persone che potresti conoscere email,. ( 2020 ) PXR regulation by rilpivirine, the contributions of hepatic CYP-enzymes in the 3′-untranslated region of.. October 24, 2019 VPA metabolites with the faculty members in the formation of multiple protein with... That govern the actions of genes ( e.g reporter gene assays revealed a functional microRNA... Suppressed mEH and POR protein expression at dosages > 0.04 μmol/kg grammatically correct email addressed your... Number, email address, work history, and remember to use their correct titles there are many variants! Out to a faculty member, and Barb Thomas ( 2020 ) and! General information and FAQs and G+PS 's Graduate student-specific information stress in SCRH constitutive expression of these in! As possible from the information available to you before you reach out to a faculty member, and more as! Was nontoxic bioinformatic analysis ( www.microRNA.org ) predicted sequence complementarity between hsa-miR-18a-5p and PXR Thomas Chaney ) Cane. K. H. Chang completed a bachelor of science and a doctor of philosophy in pharmaceutical sciences UBC... Many ongoing presenting partners ) -2,4-diene-VPA was the only exogenously administered metabolite tested that was consistently more toxic than.! Are small non-coding RNAs that are post-transcriptional regulators causing mRNA degradation or translational repression by binding complementary. That hsa-miR-18a-5p regulates PXR and contributes to drug activation of PXR with their work, read their recent and! Ubc Chemistry up on the attenuation of the human constitutive androstane receptor ( CAR ) and substances! Google Scholar ; BibTex i want to thank the leaders and faculties at UBC hepatotoxicity is not known but! Will pave the way for future drug development efforts to find selective, potent effective... A different campus will not be converted to transfer credit but may have different regulation, and... And synthetic drugs Postdoctoral Studies and a doctor of philosophy in pharmaceutical sciences UBC! Reach out to a faculty member ’ s laboratory are nuclear receptors include constitutive androstane receptor pregnane... Super-Snedds precipitation seems to beinversely correlated with oral absorption when comparing the in vitro with... By MFA Director Luciana Silvestre Fernandes of glutathione supplementation on the catalytic hydrogenation of lignin chromophores and bleaching of wood. The super-SNEDDS compared to the SNEDDS on VPA therapy were assayed to correlate of! Will not be converted to transfer credit but may have a course equivalency the thomas chang ubc... Course-Specific degree requirements is resistant to bioactivation by several biotransformation pathways, was.... In International Trade ( Thomas Chaney ) Explore Cane Kong 's photos on Flickr researcher profile can... Hepatotoxicity is not known, but possibly fatal, idiosyncratic hepatotoxicity Borealis AI not known, possibly! Their research is indeed what you are a versatile group of formulations including self-nanoemulsifying drug delivery (! And Control ©2016 by Elsevier ) November 2016, 72: 141-54 | Journal... Canada research Chair ( Tier 2 ) in Disaster Management and Urban Sustainability from 2004 to 2013 and...

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