Sage Therapeutics, Inc., a biopharmaceutical company, develops and commercializes medicines to treat central nervous system disorders. Found inside Page 11486( USA ISSN 1521-0103 ) American Society for Pharmacology and Experimental Therapeutics ( ASPET ) . staff ( USA ) Sage Publications , Inc. 6645 JOURNAL OF PHARMACY PRACTICE Online - full text edition . ( USA ) Sage Publications Sage office in Raleigh | Sage Therapeutics Careers. With the prospects for its Alzheimer's drug aducanumab still up in the air, Biogen has moved to shore up its late-stage pipeline with a $3 billion licensing deal with Sage . View source version on businesswire.com: https://www.businesswire.com/news/home/20200910005195/en/, Investor Contact Global Markets Direct's, 'Sage Therapeutics, Inc. - Product Pipeline Review - 2016', provides an overview of the Sage Therapeutics, Inc.'s pharmaceutical research and development focus. Clinical Program Updates: Although an important approval that drove the company's market value to almost $9 billion, PPD is a . Found inside Page 626D.SAO, Spi Pharmaceuticals Inc D.SAP, Summit Bancorp Inc Washington. D STD, Sage Alerting Systems Inc. D STE, Ssp Pipeline Holdings Inc . D STG, All rights reserved. Sage Therapeutics, Inc., a biopharmaceutical company committed to developing novel therapies with the potential to transform the lives of people with debilitating disorders of the brain, today . With this approach, weve generated compelling data. Sage Therapeutics Announces Third Quarter 2019 Financial Results and Highlights Pipeline and Business Progress ZULRESSO (brexanolone) CIV injection revenues of $1.5M in third quarter Enrollment . He previously joined the Sage Board of Directors in October of 2020. The company owns . Today, Sage Therapeutics, Inc. (NASDAQ: SAGE), a biopharmaceutical company committed to developing novel therapies with the potential to transform the lives of people with debilitating disorders of the brain, will host "FutureCast: An R&D Portfolio Review" to discuss the Company's research and development strategy, and clinical progress in its key depression, neurology, and . Found insideTherapeutic Advances In Cardiovascular Disease can be contacted at: SAGE Publications, Therapy in Acute Coronary Syndromes: What is New in the Pipeline? Sage is advancing a portfolio of novel and differentiated product candidates designed to improve brain health by targeting the GABA and NMDA receptor systems. This book informs readers about the latest research and the most promising and effective programmes for understanding, preventing and controlling juvenile delinquency. Now the company is working to break into the broader depression market with SAGE-217. However, that potential development opportunity is balanced against the depth of other work which is still possible, we think, within MDD.. The company is heavily institution owned, with 88% ownership. Found inside SIGMA-ALDRICH CORP Saforis; MGI PHARMA INC SAGE; GENZYME ONCOLOGY Saizen; INDEVUS PHARMACEUTICALS INC Sanctura XR; ALLERGAN INC SANCTURA XR; Announced positive topline data from pivotal WATERFALL Study of zuranolone in . Powered by Madgex Job Board Software. Found inside Page 118138-160 ) Availability : SAGE Publications , Inc. , 2455 Teller Road Moreover , aspects of therapeutic interaction that are more largely engaged in by Here's Why Sage Therapeutics Lost 53.3% in December. In the ARCHWAY trial, a Phase II study of SAGE-217 in adults with moderate to severe bipolar I/II disorder with a major depressive episode, patients showed a rapid and durable response to treatment and statistically significant improvement compared to baseline. SAGE Therapeutics is searching for a creative, resourceful, integrative thinker for a strategic leader responsible for leading cross-functional teams tasked to develop Proactive Disease Strategies . It is also being studied for bipolar depression and additional affective disorders, including treatment-resistant depression (TRD) and generalized anxiety disorder (GAD). Combining both the theory and practice of strengths-based therapy, Elsie Jones-Smith introduces current and future practitioners to the modern approach of practicepresenting a model for treatment as well as demonstrations in clinical Published: Jul 25, 2019 Those value metrics, along with a pipeline of drugs that includes Zuranolone, make it worth . We are pursuing new pathways with the goal of improving brain health, and our depression, neurology and neuropsychiatry franchise programs aim to change how brain . For more information, please visit www.sagerx.com. Sage Therapeutics Slashes 53% of Workforce to Focus Resources on Pipeline. It has received Breakthrough Therapy Designation from the FDA for MDD. Found insideThe framework highlights the need to (1) support research to strengthen the evidence base on the efficacy and effectiveness of psychosocial interventions; (2) based on this evidence, identify the key elements that drive an intervention's Media Contact Sage Therapeutics Inc . Sage office in Raleigh | Sage Therapeutics Careers. It has an outstanding patent estate, with zuranolone . Benefits. No dropouts were made over adverse side effects. The successful candidate will be responsible for establishing and managing the clinical supply chain for Sage's products, and for supporting products in the clinical stage from a supply chain perspective. Our pipeline includes four differentiated clinical-stage central nervous system (CNS) therapies targeting significant and growing markets. The agreement includes development of two candidate from Sage Therapeutics' pipeline zuranolone (SAGE-217) and SAGE-324. The live webcast can be accessed on the investor page of Sage's website at investor.sagerx.com. Sage Therapeutics to Provide Pipeline Update at J.P. Morgan Healthcare Conference and Outline Key 2018 Initiatives to Support Planned Evolution to a Fully-Integrated Commercial Biopharmaceutical . We explicitly disclaim any obligation to update any forward-looking statements. Found insideThis remarkable text reveres the lifelong commitment of using knowledge and skills as power for good to make a meaningful difference in peoples lives. Various statements in this release concern Sage's future expectations, plans and prospects, including without limitation: our views and expectations regarding the potential of our product candidates in various indications, the potential profile and benefit of our product candidates, and the goals, opportunity and potential for our business. We think it is the nearest term value driver and we believe that it will position SAGE-217, if and when it launches, to really be, we hope, one of the most valuable assets to be introduced in the major depression space, Jonas said in the webcast. SAGE CENTRAL, the SAGE CENTRAL logo, ZULRESSO, the ZULRESSO logo, SAGE THERAPEUTICS, and the SAGE THERAPEUTICS logo are trademarks of Sage Therapeutics, Inc. Biogen and Sage enter into an agreement to jointly develop and commercialize zuranolone and SAGE-324 in the U.S.; Biogen to receive exclusive license to develop and commercialize zuranolone and SAGE-324 outside of the U.S., excluding rights to zuranolone in Japan, Taiwan and South Korea; Sage Therapeutics to receive $1.525 billion in cash comprised of an upfront payment of $875 million and a . Our Pipeline | Sarepta Therapeutics. We have built a growing pipeline of investigational therapeutics. Today, Sage Therapeutics, Inc. (NASDAQ: SAGE), a biopharmaceutical company committed to developing novel therapies with the potential to transform the lives of people with debilitating disorders of the brain, will host FutureCast: An R&D Portfolio Review to discuss the Companys research and development strategy, and clinical progress in its key depression, neurology, and neuropsychiatry franchise programs. Today, Sage Therapeutics, Inc. (NASDAQ: SAGE), a biopharmaceutical company committed to developing novel therapies with the potential to transform the lives of people with debilitating disorders of the brain, will host "FutureCast: An R&D Portfolio Review" to discuss the Company's research and development strategy, and clinical progress in its key depression, neurology, and neuropsychiatry . We have different types of field-based roles throughout the United States. About Sage Therapeutics Sage Therapeutics is a biopharmaceutical company committed to developing novel therapies with the potential to transform the lives of people with debilitating disorders of . . Sage Therapeutics Announces Second Quarter 2021 Financial Results and Highlights Pipeline and Business Progress Announced positive topline data from pivotal WATERFALL Study of zuranolone in patients with MDD showing statistically significant and clinically meaningful reduction in depressive symptoms at Day 15, primary endpoint Found inside Page 140 knowledge about our pipeline, brands, and therapeutic areas (up 143 percent). For instance, Celgene announced in October 2016 an alliance with Sage At Day 42 or 45, the last day of the study, patients receiving the drug had a 4.9-point greater reduction in HAM-D-17 compared to placebo. Investors: learn more about Sage's pipeline and approach to developing treatments for brain health disorders. Sage Therapeutics Announces Second Quarter 2021 Financial Results and Highlights Pipeline and Business Progress Aug 3, 2021 Aug 3, 2021 Updated Aug 3, 2021 We've set up base in Research Triangle . This edited book brings together the latest research on how group memberships, and the social identities associated with them, determine people's health and well-being. A replay of the webcast will be available on Sage's website approximately two hours after the completion of the event and will be archived for up to 30 days. It's time to discover your future with Sage. -. 1985 - 2021 BioSpace.com. [emailprotected]. The company discussed its pipeline at its FutureCast., Our goal at Sage has always been to step into the void in CNS drug development through an innovative approach we believe to be unique, stated Jeff Jonas, Sages chief executive officer. That left the door open for a new competitor. Manager, Clinical Supply Chain. Our Sage office in Raleigh, North Carolina is home to our Patient Support team. In this brief volume, James A. Holstein and Jaber F. Gubrium outline the differences between the active interview and the traditional interview and give novice researchers clear guidance on conducting an interview that is the rich product . Thinking differently about thinking Development plans for SAGE-718 focused on executive function across multiple indications, Early learnings from studies of other compounds created multi-faceted insights for SAGE-324 program in essential tremor, Interview with investigator from SHORELINE study highlights potential for multiple approaches in the treatment of MDD, Additional details about Phase 3 trial with brexanolone in COVID-19 related ARDS. Field. RNA Technologies. Following a setback with its experimental major depressive disorder drug in December, SAGE Therapeutics will initiate a corporate restructuring that includes halving its employee headcount in order to focus its resources on the development of its pipeline. Found inside Page 269 includes multiple pathways in therapeutic services, diagnostic services, while opening a talent pipeline in growth industries that are strategic to Making Medicines Affordable examines patient access to affordable and effective therapies, with emphasis on drug pricing, inflation in the cost of drugs, and insurance design. The inspiration for the PBS series Mysterious of Mental Illness, Shrinks brilliantly tells the "astonishing" story of psychiatry's origins, demise, and redemption (Siddhartha Mukherjee). Found inside Page 415Cablevision Systems Corporation GUSMAN, LARRYSAP America, Inc. HARROLD,JEFFREYS. HEATHERCharter Communications SAGE, JUSTIN L.Roche Diagnostics Sage expects to complete certain ongoing Phase 1 clinical studies for two programs in its early development pipeline in late 2021, SAGE-689 and SAGE-904. December 31, 2016. Sage Therapeutics' FutureCast to Provide Update on Pipeline Progression and Additional Insights into Potential of Brain Health Franchises Published Sep 10, 2020 6:30AM EDT Sage Therapeutics Announces Restructuring to Advance Corporate Strategy and Pipeline. Previously: Sage Therapeutics EPS misses . Forward-Looking Statements Clinical Trials We are exploring new ways to think about and treat central nervous system (CNS) disorders. Its lead product candidate is ZULRESSO, an intravenous formulation of brexanolone for the treatment of postpartum depression (PPD) in adults. It is in a Phase III trial for major depressive disorder (MDD), PPD, and comorbid MDD and insomnia. Sage Therapeutics, Inc., a biopharmaceutical company, develops and commercializes medicines to treat central nervous system disorders. Advancing a Leading Brain Health Portfolio. Sage Therapeutics Announces First Quarter 2020 Financial Results and Highlights Pipeline and Business Progress Expected initiation of three new short-term zuranolone clinical studies in 2020, with . FutureCast: An R&D Portfolio Review, begins at 9:00 a.m. But from a practical strategy, there are advantages to TRD development. Found insideThe Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Sage therapeutics pipeline includes SAGE-718, a phase 2 neuropsychiatry treatment for Parkinson's, Alzheimer's, and Huntington's disease, as well as several other early development treatments for GABA hypofunction. We have recently updated our Privacy Policy to include information regarding the cookies we collect. Sage Therapeutics, Inc. and Subsidiaries Condensed Consolidated Balance Sheets (in thousands) (Unaudited). Found insideGenzyme Molecular Oncology SAGE Clolar Impath, Inc. SCAN AbSCAN Campath ILEX small-molecule drug discovery and protein therapeutic capabilities. Summary Toggle Sage Therapeutics to Present at Upcoming August Investor Conferences August 3, 2021 Summary Toggle Sage Therapeutics Announces Second Quarter 2021 Financial Results and Highlights Pipeline and Business Progress FutureCast will feature the following topics and speakers: Sages approach to exploratory clinical research and the questions we ask, Sages NMDA Discovery Efforts: An emerging platform of NMDAr modulators, SAGE-324: Novel potential treatment for chronic neurological conditions, Zuranolone: Exploring the fundamentals of an as needed treatment in major depressive disorder (MDD), Brexanolone and COVID-19 related acute respiratory distress syndrome (ARDS). So they're used to working in the mood and anxiety disorder neck of the woods. Our Pipeline. While these are still early data, we believe these data not only meaningfully expand our pipeline opportunities, but more importantly, represents the potential benefits our medicines may provide for patients if were successful in our development efforts.. Bloomberg the Company & Its Products The Company & its Products Bloomberg Terminal Demo Request Bloomberg Anywhere Remote Login Bloomberg Anywhere Login Bloomberg Customer Support Customer Support The resulting cost savings are comprised of a . Axsome Therapeutics has built a portfolio of differentiated product candidates that address areas of high unmet medical needs. We are Sage Therapeutics, and we're on a fiercely committed journey of discovery, with the ultimate aim of truly enhancing the lives of people who live with CNS disorders. Sage Therapeutics is searching for a creative, resourceful, integrative thinker for a highly visible role that serves as the primary SAGE external medical expert in a defined region, providing advanced. Sage Therapeutics believes there are 18 million people in the U.S. suffering from postpartum depression and major depressive disorder, and management also believes that their current pipeline has . The company plans to also develop the drug for TRD but expects to discuss it in the future. Prior to Sage, he served as president of Alnylam Pharmaceuticals, Inc. since 2007, and he previously held the position of chief . It's significant that Sage specializes in novel medicines for disorders of the brain and Biogen targets neurological diseases. Emily Gusse Director, Pipeline Advocacy and Strategic Advocacy Programs at Sage Therapeutics Greater Boston 500+ connections SAGE-217 is the companys next-generation positive allosteric modulator (PAM) of GABAA receptors. CAMBRIDGE, MA, USA I April 12, 2021 I Sage Therapeutics, Inc. (Nasdaq: SAGE) and Biogen Inc. (Nasdaq: BIIB) today reported topline results from the Phase 2 KINETIC Study evaluating SAGE-324 in the treatment of people with essential tremor (ET). AXS-05 Major Depressive Disorder: Breakthrough Therapy Designation Alzheimer's . Developing a deep, sustainable pipeline of novel neurobehavioral therapeutics. Thinking differently about thinking - Development plans for SAGE-718 focused on executive function across multiple indications. Found inside Page 109Another U.S. acquisition was attempted in 2009, the biotechnology firm CV Therapeutics Inc., but it was acquired by Gilead Sciences instead. Major Depressive Disorder pipeline comprises therapies in different stages of the clinical phase such as include Vraylar, PDC-1421, AV-101, AXS-05, Pramipexole, SAGE-217, LY03005, Seltorexant . These forward-looking statements are neither promises nor guarantees of future performance, and are subject to a variety of risks and uncertainties, many of which are beyond our control, which could cause actual results to differ materially from those contemplated in these forward-looking statements, including the risks that: success in our non-clinical studies or in earlier clinical trials may not be repeated or observed in ongoing or future studies, and ongoing and future non-clinical and clinical results may not meet their primary or key secondary endpoints or be sufficient to file for or gain regulatory approval to market a product without further development work or may not support further development at all; we may encounter adverse results or adverse events at any stage of development that negatively impact further development or that require additional nonclinical and clinical work which may not yield positive results; we may encounter different or more severe adverse events at the higher doses we are studying in our new trials; we may encounter issues with the efficacy or durability of short-term treatment, or co-initiated treatment with zuranolone or safety and efficacy concerns with respect to retreatment that require additional studies be conducted; we may encounter delays in initiation or conduct of our ongoing and planned clinical trials, including slower than expected site initiation or enrollment, that may impact our ability to meet our expected time-lines and increase our costs; we may not be able to mitigate the impact of COVID-19 on our clinical development timelines and the impact may be more significant than we expect and may negatively impact expected site initiation, enrollment or conduct in our clinical trials, or cause us to pause trials or not be able to use data, in each case which may significantly impact our ability to meet our expected time-lines or may significantly impact the integrity or sufficiency of the data from our trials or increase our costs or cause us to have to change our plans; the FDA may ultimately decide that the design or results of our completed and planned clinical trials for any of our product candidates, even if positive, are not sufficient for regulatory approval in the indications that are the focus of our development plan; other decisions or actions of the FDA or other regulatory agencies may affect the initiation, timing, design, size, progress and cost of clinical trials and our ability to proceed with further development; we may encounter technical and other unexpected hurdles in the development and manufacture of our product candidates which may delay our timing or change our plans or increase our costs; as well as those risks more fully discussed in the section entitled "Risk Factors" in our most recent Quarterly Report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the Securities and Exchange Commission. , we ve generated compelling data, Sage Alerting Systems Inc. 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